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Mr Aleksandrs Čižikovs (Latvian Institute of Organic Synthesis)17/03/2023, 09:00
In the last few decades transition metal-catalyzed direct C-H bond functionalization has served as a valuable tool for the construction of complex molecules from more simple starting materials, mainly due to its atom- and step-economical nature. Nowadays, the field of third row transition metal catalyzed C-H functionalization is being extensively studied as a cheaper and attractive alternative...
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Rasma Kroņkalne (RTU)17/03/2023, 09:20
Small heterocycles, particularly those containing a 5-membered cycle, are popular motifs in pharmaceuticals, displaying a broad range of biological properties [1]. A well-established strategy for the synthesis of 5-membered saturated/partially saturated heterocycles involves intramolecular cyclization, made possible by internal nucleophile attack on carbocations.
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In this work we investigate... -
Rūdolfs Beļaunieks (Riga Technical University)17/03/2023, 09:40
The ease of the unsaturated system reactivity proceeding via -silyl carbocation ion can be explained by the stabilizing effects of the silicon-carbon bond interaction with carbocation ion - known as -silicon effect. This can be achieved by either vertical (hyperconjugation) or non-vertical (formation of cyclic silonium ion) stabilization. The formation of the latter, in combination with...
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Kristaps Leškovskis (Riga Technical University)17/03/2023, 10:00
Heterocycles with an azido-azomethine structural entity are interesting due to their intrinsic dynamic azide-tetrazole tautomeric equilibrium in the solution phase [1] alongside rich azide functional group chemistry [2].
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Herein, a method for the synthesis of 5-substituted tetrazolo[1,5-a]pyrido[2,3 e] pyrimidines from 2,4-diazidopyrido[3,2-d]pyrimidine in SNAr reactions with N-, O-, and S ... -
Artūrs Sperga (Latvian Institute of Organic Synthesis)17/03/2023, 10:20
Synthesis of fluorine containing molecules is of great interest due to its unique properties and vast application in pharmaceuticals, agrochemicals and materials [1].
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Previously in our group we have developed fluoromethylene transfer from fluromethylsulfonium salts [2, 3]. Herein we wish to report preliminary results on synthesis of reagents 1 and its initial application in carbene transfer... -
Vladislavs Kroškins (RTU, OĶTI.)17/03/2023, 10:40
C-H activation of betulin, oleanolic acid and ursolic acid
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Aleksejs Burcevs (Riga Technical University)17/03/2023, 11:00
Target purine compound 2 was designed with an aim to be used as a potential system for photo-catalysis. For the synthesis of 2, derivatization of C(6), C(8) and N(9) positions of 6-chloropurine (1) with A, B and C moieties is required. Several synthetic pathways were designed and have been tested. In the end, target compound 2 was obtained, using the...
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Mr Georgijs Stakanovs (Latvian Institute of Organic Synthesis)17/03/2023, 11:20
β-Caryophyllene is one of the most abundant sesquiterpenes found in nature, therefore it is available at low price from several commercial sources. The unusual structure of β-caryophyllene with two stereodefined chiral centers renders this terpene an attractive renewable starting material for the access of diverse high value compounds.
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We demonstrate that β-caryophyllene and its oxide can be... -
Emīls Bašēns (Latvian Institute of Organic Synthesis)17/03/2023, 12:20
In the last couple of decades, high-valent cobalt catalysis has been used as a valuable tool for C-H bond activation and functionalization.1 The use of cobalt(II) salt catalysts in combination with bidentate directing groups has proven to be an effective strategy for various C-H bond transformations.2,3 With cobalt being less expensive alternative to noble metals, it also displays unique...
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Laura Pauniņa17/03/2023, 12:40
Laura Pauniņa1, Cristina Durante Cruz2, Marina Madre1, Tania Szal3, Päivi Tammela2, Aigars Jirgensons1, Björn Windshügel3, Jānis Veliks1
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1 Latvian Institute of Organic Synthesis, Aizkraukles 21, LV-1006, Riga, Latvia
2 Drug Research Program, Division of Pharmaceutical Biosciences, Faculty of Pharmacy, University of Helsinki, Finland P.O. Box 56 (Viikinkaari 5E), FI-00014, Helsinki,... -
Oto Filipsons17/03/2023, 13:00
Pyridine and its derivatives are often used as effective nucleophilic catalysts for reactions such as the Baylis-Hillman reaction, acyl group transfer reactions and others. A noteworthy example is DMAP which is a widely known acylation reaction catalyst. Alcohol acylation reactions can also be catalysed by isochalcogenurea derivatives which exhibit a 1,5-O···Ch interaction in the acylated...
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Niklāvs Ūdris (Latvian Institute of Organic Synthesis)17/03/2023, 13:20
Abstract
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Jānis Šadauskis17/03/2023, 13:40
Cancer has a major impact on society around the world and it is one of the leading causes of death. IRE1α is an enzyme that plays a part in the development of certain cancers, such as breast cancer, colon cancer, and prostate cancer. IRE1α inhibitors might be used to treat these types of cancer. [1]
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The aim of this study was to find IRE1α inhibitors that would have a greater selectivity and... -
Vitalii Solomin17/03/2023, 14:00
Quinazolines and indazoles can be synthesized starting from 2-formylphenylboronic acids using copper-promoted C-N bond formation with subsequent heterocyclization.
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Ms Anastasija Balašova (Latvian Institute of Organic Synthesis)17/03/2023, 14:20
Carbonic anhydrases (CA, EC 4.2.1.1) are essential metalloenzymes found across all kingdoms of life. These enzymes are involved in many important physiological processes, as they catalyse the reversible hydration of carbon dioxide [1]. To date, 15 different human CA isoforms have been identified, out of which CA IX and XII isoforms are highly overexpressed in different tumour types and may...
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Ms Katrina Prane17/03/2023, 14:40
One of the oldest methods in electroorganic synthesis is Kolbe reaction, where alkyl radical is generated upon anodic decarboxylation. In contrast, Hofer-Moest reaction provides a carbocation after anodic decarboxylation followed by a reaction with a nucleophile.
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Aminomalonic acid derivatives are readily available substrates that can be relatively easily functionalized, e.g. by alkylation... -
Artūrs Mazarevičs (Latvian Institute of Organic Synthesis)17/03/2023, 15:00
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Artūrs Šilaks (University of Latvia)17/03/2023, 15:20
SYNTHESIS AND USE OF NOVEL MOLECULARLY IMPRINTED POLYMERS FOR SELECTIVE EXTRACTION OF CATECHOLAMINES AND THEIR METABOLITES
JAUNU MOLEKULĀRI IMPRINTĒTU POLIMĒRU SINTĒZE UN TO PIELIETOŠANA SELEKTĪVAI KATEHOLAMĪNU UN TO METABOLĪTU CIETFĀZES EKSTRAKCIJAI
Artūrs Šilaks, Antons PodjavaLaboratory of Chromatography and Mass Spectrometry, Department of Chemistry, Academic Center of Natural...
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