Organic Chemistry

Session

Oral Presentations

11 Feb 2022, 09:40

1. SYNTHETIC APPROACH TOWARDS ENANTIOPURE CYCLIC SULFINAMIDES

Jersovs, Glebs (Latvijas Universitāte; Latvijas Organiskās sintēzes institūts)

11/02/2022, 09:40

Oral Presentation

Oral presentation

N-Alkylation of readily accessible Ellman’s sulfinamide derivatives has become a routine step in preparation of enantiopure amines. On the other hand, rarely exploited nucleophilic character of the S-atom in tert-butyl sulfinamides can be revealed in a serendipitously discovered intramolecular alkylation. High regio- and stereoselectivity of this transformation allows for facile...

2. SYNTHESIS OF 2-AMINOQUINAZOLINES AND INDAZOLES FROM 2-FORMYLPHENYLBORONIC ACIDS

Solomin, Vitalii

11/02/2022, 10:00

Oral Presentation

Oral presentation

New method for the synthesis of substituted indazoles and 2-aminoquinazolines has been studied and developed. Using invented technique, 2-formylphenylboronic acids can be converted to the target heterocycles in a mild conditions.

4. A MECHANISTICAL STUDY OF LEWIS BASE CATALYZED CYANOHYDRIN SYTHESIS

Feldmanis, Artūrs Raimonds (Latvian Institute of Organic Synthesis, University of Latvia)

11/02/2022, 10:20

Oral Presentation

Oral presentation

Enantiopure cyanohydrins are valuable building blocks in organic and medicinal chemistry [1]. Both functional groups of cyanohydrins (nitrile and hydroxy group) can be easily modified giving access to a variety of valuable organic compounds such as α‑amino acids, α‑hydroxy acids and aziridines.
Herein we present chiral Lewis base-catalyzed synthesis of enantioenriched cyanohydrins...

3. DEVELOPMENT OF SYNTHESIS PATHWAYS FOR THE LIMONOID OCTAHYDRO-1H-2,4-METHANOINDENE SCAFFOLD

Rāciņš, Olavs

11/02/2022, 10:40

Oral Presentation

Oral presentation

The octahydro-1H-2,4-methanoindene scaffold is present in various limonoid natural products, such as phragmalin, xyloccensins and others. Limonoid natural products exhibit a wide range of pharmacological properties, including anti-HIV, antibiotic, anti-cancer, anti-malarial, and anti-viral activities, therefore, are of high synthetic interest.

In this work, we explore a pathway for a...

5. COBALT-CATALYZED AMINO ACID C(sp2)-H BOND FUNCTIONALIZATION USING ORGANIC ISOCYANIDES

Čižikovs, Aleksandrs (Latvian Institute of Organic Synthesis)

11/02/2022, 11:00

Oral Presentation

Oral presentation

Over the last decade, high-valent cobalt catalysis has earned a place in the spotlight as a valuable tool for C-H activation and functionalization. The use of cobalt (II) salt catalysts in combination with bidentate directing groups has been proven to be an effective strategy for various C-H bond transformations. Not only cobalt is less expensive alternative to third row noble metals, but also...

12. NEW SYNTHETIC APPROACH FOR THE SYNTHESIS OF SUBSTITUTED 7-ARYLPURINES

Sebris, Armands

11/02/2022, 11:20

Oral Presentation

Oral presentation

Alkylation and arylation on the purine ring usually proceeds almost selectively at N(9) position. While there are some simple pathways to introduce alkyl substituents at N(7) [1], the same is not true for introduction of aryl groups. The most commonly used Cu catalyzed Chan-Lam reaction [2] and arylation with iodanes [3] selectively give N(9) product. The few existing methods for purine N(7)...

9. C-H ACTIVATION OF LUPANE TYPE TRITERPENOIDS

Kroškins, Vladislavs (RTU)

11/02/2022, 11:40

Oral Presentation

Oral presentation

.