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Dr Sokolovs, Igors (Latvian Institute of Organic Synthesis)11/02/2022, 09:00
The chemistry of hypervalent halogen species has experienced enormous progress in the last decades, and hypervalent iodine (III) compounds have become common reagents in modern organic synthesis. In sharp contrast, the chemistry of isoelectronic bromine (III) compounds occur to be notably less advanced to date. This dramatic difference obviously is to be connected with the relatively low...
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Jersovs, Glebs (Latvijas Universitāte; Latvijas Organiskās sintēzes institūts)11/02/2022, 09:40
N-Alkylation of readily accessible Ellman’s sulfinamide derivatives has become a routine step in preparation of enantiopure amines. On the other hand, rarely exploited nucleophilic character of the S-atom in tert-butyl sulfinamides can be revealed in a serendipitously discovered intramolecular alkylation. High regio- and stereoselectivity of this transformation allows for facile...
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Solomin, Vitalii11/02/2022, 10:00
New method for the synthesis of substituted indazoles and 2-aminoquinazolines has been studied and developed. Using invented technique, 2-formylphenylboronic acids can be converted to the target heterocycles in a mild conditions.
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Feldmanis, Artūrs Raimonds (Latvian Institute of Organic Synthesis, University of Latvia)11/02/2022, 10:20
Enantiopure cyanohydrins are valuable building blocks in organic and medicinal chemistry [1]. Both functional groups of cyanohydrins (nitrile and hydroxy group) can be easily modified giving access to a variety of valuable organic compounds such as α‑amino acids, α‑hydroxy acids and aziridines.
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Herein we present chiral Lewis base-catalyzed synthesis of enantioenriched cyanohydrins... -
Rāciņš, Olavs11/02/2022, 10:40
The octahydro-1H-2,4-methanoindene scaffold is present in various limonoid natural products, such as phragmalin, xyloccensins and others. Limonoid natural products exhibit a wide range of pharmacological properties, including anti-HIV, antibiotic, anti-cancer, anti-malarial, and anti-viral activities, therefore, are of high synthetic interest.
In this work, we explore a pathway for a...
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Čižikovs, Aleksandrs (Latvian Institute of Organic Synthesis)11/02/2022, 11:00
Over the last decade, high-valent cobalt catalysis has earned a place in the spotlight as a valuable tool for C-H activation and functionalization. The use of cobalt (II) salt catalysts in combination with bidentate directing groups has been proven to be an effective strategy for various C-H bond transformations. Not only cobalt is less expensive alternative to third row noble metals, but also...
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Sebris, Armands11/02/2022, 11:20
Alkylation and arylation on the purine ring usually proceeds almost selectively at N(9) position. While there are some simple pathways to introduce alkyl substituents at N(7) [1], the same is not true for introduction of aryl groups. The most commonly used Cu catalyzed Chan-Lam reaction [2] and arylation with iodanes [3] selectively give N(9) product. The few existing methods for purine N(7)...
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Kroškins, Vladislavs (RTU)11/02/2022, 11:40
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Dr Pelšs, Andrejs (Latvian Institute of Organic Synthesis)11/02/2022, 13:00
Latvian Institute of Organic Synthesis, Aizkraukles 21, Riga LV-1006, Latvia
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e-mail:a-pelss@osi.lv
Prostanoids are important class of potent lipid mediators that are involved in the regulation of many biological processes such as inflammation, pain response and fever. This class of compounds has found wide-spread use as pharmaceuticals for the treatment of several diseases including... -
Leškovskis, Kristaps (Institute of Technology of Organic Chemistry, Riga Technical university)11/02/2022, 13:40
Azido groups in nitrogen heterocycles, if adjacent to annular nitrogen, can spontaneously cyclize to fused tetrazole or at least persist in azide-tetrazole equilibrium [1]. Azide-tetrazole valance tautomerism is considered as a reversible intramolecular 1,5-dipolar cycloaddition with azide tautomer being thermodynamically more stable. However, azide formation is endothermic process, thus azide...
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Kriķis, Kārlis (Student)11/02/2022, 14:00
Purine derivatives have been studied not only as biologically active compounds but also as scaffolds for OLED materials. Recently, purine based derivatives have shown promising results as TADF (thermally activated delayed fluorescence) materials [1].
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In this study we have designed new purine-thiazolopyrimidine conjugates A and E containing phenylanthracene moiety, later to be studied as TADF... -
Sloboda, Diāna (LU ĶF)11/02/2022, 14:20
Since 2002 when Meldal [1] and Sharpless [2] independently discovered a copper effect on azide-alkyne cycloaddition (Huisgen reaction), the copper(I) catalyzed azide-alkyne cycloaddition (CuAAC) reaction has gained a popularity and attention from scientists in various fields. CuAAC can be carried out in a variety of molecular solvents ranging from the nonpolar toluene and dichloromethane, to...
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Meiberga, Mērija Agnese11/02/2022, 14:40
α – Amino acids are widely used in drug design and peptide chain synthesis. Proline is the only cyclic natural amino acid, therefore its conformational rigidity plays an important role in protein secondary structures, such as alpha helices.
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Herein we report the synthesis of previously unreported bicyclic amino acid derivatives 4 substituted at bridgehead positions. These amino acids are even... -
Ruduss, Armands (Riga Technical University)11/02/2022, 15:00
Highly luminescent two coordinate linear carbene-metal-amide (CMA, metal= Cu, Ag, Au) complexes with short radiative lifetimes have emerged as a highly promising direction towards TADF materials [1,2]. However, structural diversity of CMAs with potential OLED application is still limited to a handful of N-heterocyclic carbene (NHC) structures. In this report we demonstrate luminescent CMAs...
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Bazulis, Maris (Latvian Institute of Organic Synthesis)11/02/2022, 15:20
The abstract is in the attachment.
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Bašēns, Emīls (Latvian Institute of Organic Synthesis)11/02/2022, 15:40
Malaria is a deadly parasitic infection caused by Plasmodium parasites. The widespread resistance against available antimalarial drugs motivates scientists to develop new therapeutic agents targeting the life cycle of the parasite by novel mechanisms of action.
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Plasmepsins (plm) are malarial aspartic proteases which have been proposed as appropriate antimalarial drug targets. It is important...
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