A non-intrusive multi-dimensional analysis method can be useful in many pharmaceutical applications, especially for the analysis of solid dosage forms, where spatial information using conventional analytical methods can typically only be obtained after destructive manipulations with samples prior to or during the measurements. This study demonstrated a new combination method of low-frequency...
Due to the dominating Coulombic interactions, packing of ions in ionic liquids (ILs) solely depends on ion shape and size. The free volume in ILs is thus generally smaller than in molecular liquids. The low volatility and structural tuneability of ILs make them attractive for applications involving gaseous solutes. Greater free volume can entropically contribute to absorption of gases and, for...
Selectivity is a major issue in the development of drugs targeting pathogen aspartic proteases. Here we explore the selectivity determining factors by studying specifically designed malaria aspartic protease (plasmepsin) open-flap inhibitors. 2-Aminoquinazolin-4(3H)-one based plasmepsin inhibitors with various flap pocket substituents are synthesized and their potencies against several...
Introduction. It has been shown that determination of reference intervals (RI) using accumulated general patient data can be a cost effective alternative [3] to special research following C28-A3 guidelines[1].
There are some reports on B12 RI for different ethnicities [2]. There is little and somewhat contradictory information about the B12 RI for different age groups and sexes. In this work...
Malaria infection in humans is caused by Plasmodium Falciparum parasite. P. Falciparum aspartic proteases (plasmepsins) are responsible for catalytic hemoglobin degradation and thus are being investigated as potential drug targets. Plasmepsins, however, share high structural similarity with human aspartic proteases, emphasizing the need for selective inhibitors. Selectivity of several...
Metal–organic frameworks (MOFs) have been known for decades, and they continuously have gained interest because of their application potential increasing in the various fields – pharmacy, medicine, technology etc [1]. MOFs porous architecture and adjustable properties allow them to be considered as promising drug carriers. Modification of the properties of an existing active pharmaceutical...
University of Latvia, Faculty of Chemistry, Jelgavas iela 1, Riga, Latvia
e-mail: ainasemjonova@gmail.com
Active pharmaceutical ingredients (APIs) can have different physical properties (e.g., solubility [1] and bioavailability) depending on polymorph form. Many APIs have low solubility in water. Crystallization of metastable form can enhance solubility and bioavailability [2]....
Solid solutions (SS) are single multicomponent solid phases for which the constituent component ratio can vary in continuum. Along with the composition, also properties of solid solutions are modulated. The changes in composition are often accompanied by a continuous change in some physical and/or chemical properties (e.g., density, solubility, melting point), and more complex properties such...
Cyclodextrins (CD’s) are cyclic oligosaccharides widely used in pharmaceutical, food and cosmetic industries as excipients and stabilizers. They are produced by enzymatic transformation of starch, obtained from renewable green sources (potato, corn, etc.). This process is unselective and typically leads to a formation of a mixture of CD’s with various numbers of glucose subunits in the cycle...
Sheep breeding in Latvia in the last decade is stabilized and continues to develop. Since sheep breeding includes producing of wool, it is important for fabrication of textiles and thermoinsulators. However, annually tons of wool fibers, that do not fit to requirements to be used in textile industry, remain as residues. Such wool can be used as sorbent [1] or convert in activated carbon [2]...
Medical radionuclides as $^{43,44m, 44g,47}$Sc are very promising in “matched theranostic pair” radiopharmaceutical development for cancer treatment. Use of natural titanium as target material for production of $^{43,44m, 44g,47}$Sc radionuclides is favorable in terms of cost and the wide availability of target material, in contrast of using low abundant enriched Ca targets. We report here the...
Lithium orthosilicate (Li4SiO4) and lithium metatitanate (Li2TiO3) for radiation-induced defect studies have been made using numerous methods including sol-gel, melt-spraying, drip-casting and solid-state reaction process in order to evaluate radiation stability of material for application as tritium breeding ceramics in future thermonuclear fusion reactors [1,2]. Solid-state reaction process...
Metallic nanoparticle dispersions for conducting ink preparation
Aleksandrs Novikovs, Boriss Poļakovs
Institute of Solid State Physics, University of Latvia
e-mail: aleksandrs.novikovs@cfi.lu.lv
The aim of this research is to prepare conducting nanoparticle inks, such that it would be possible to print electrical components using a functional ink-jet printer.
Relevance of the topic...
