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Agris Berzins11/02/2022, 10:30
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Kārlis Bērziņš (University of Otago, Department of Chemistry)11/02/2022, 10:40Fizikālās ķīmijas un Analītiskās ķīmijas kopējā sēdeOral presentation
A non-intrusive multi-dimensional analysis method can be useful in many pharmaceutical applications, especially for the analysis of solid dosage forms, where spatial information using conventional analytical methods can typically only be obtained after destructive manipulations with samples prior to or during the measurements. This study demonstrated a new combination method of low-frequency...
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Zane Berzina11/02/2022, 10:55
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Dr Eduards Bakis11/02/2022, 11:10Fizikālās ķīmijas un Analītiskās ķīmijas kopējā sēdeOral presentation
Due to the dominating Coulombic interactions, packing of ions in ionic liquids (ILs) solely depends on ion shape and size. The free volume in ILs is thus generally smaller than in molecular liquids. The low volatility and structural tuneability of ILs make them attractive for applications involving gaseous solutes. Greater free volume can entropically contribute to absorption of gases and, for...
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24. Bioactivity Enhancement of Peo Coatings by Introduction of Amorphous Calcium Phosphate ParticlesVladlens Grebņevs (Faculty of Chemistry, Department of Analytical Chemistry)11/02/2022, 11:25
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Raitis Bobrovs11/02/2022, 11:40Fizikālās ķīmijas un Analītiskās ķīmijas kopējā sēdeOral presentation
Selectivity is a major issue in the development of drugs targeting pathogen aspartic proteases. Here we explore the selectivity determining factors by studying specifically designed malaria aspartic protease (plasmepsin) open-flap inhibitors. 2-Aminoquinazolin-4(3H)-one based plasmepsin inhibitors with various flap pocket substituents are synthesized and their potencies against several...
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Ingus Perkons11/02/2022, 11:55
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Dr Agris Auce (Institute of Chemical Physics, University of Latvia), Ms Agnese Miķelsone (Riga Stradins University)11/02/2022, 12:10Fizikālās ķīmijas un Analītiskās ķīmijas kopējā sēdeOral presentation
Introduction. It has been shown that determination of reference intervals (RI) using accumulated general patient data can be a cost effective alternative [3] to special research following C28-A3 guidelines[1].
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There are some reports on B12 RI for different ethnicities [2]. There is little and somewhat contradictory information about the B12 RI for different age groups and sexes. In this work... -
Toms Upmanis11/02/2022, 13:00
Crown ether chiral stationary phases have been successfully used for separating enantiomers of various racemic compounds containing primary amino groups. Although chiral recognition mechanism for crown-ether CSPs is generally understood, on a molecular level, the exact chiral recognition mechanisms for the resolution of short peptides, containing multiple amino moieties capable of binding to...
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Valda Valkovska11/02/2022, 13:15
Substantial amounts of bark of forest trees are a by-product of wood processing, a major proportion of which is used for energy production. Nevertheless, it could also be a valuable source of tannins for use as natural colourants [1]. The barks of many trees are suitable sources of reddish-brown dyes. The most frequently mentioned brown-colouring barks were tannin-rich alder, oak, hemlock and...
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Laura Drunka (Latvian Institute of Organic Synthesis)11/02/2022, 13:30
Malaria infection in humans is caused by Plasmodium Falciparum parasite. P. Falciparum aspartic proteases (plasmepsins) are responsible for catalytic hemoglobin degradation and thus are being investigated as potential drug targets. Plasmepsins, however, share high structural similarity with human aspartic proteases, emphasizing the need for selective inhibitors. Selectivity of several...
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Kristīne Krūkle-Bērziņa (Latvian Institute of Organic Synthesis)11/02/2022, 13:45
Metal–organic frameworks (MOFs) have been known for decades, and they continuously have gained interest because of their application potential increasing in the various fields – pharmacy, medicine, technology etc [1]. MOFs porous architecture and adjustable properties allow them to be considered as promising drug carriers. Modification of the properties of an existing active pharmaceutical...
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Aina Semjonova (University of Latvia)11/02/2022, 14:00
University of Latvia, Faculty of Chemistry, Jelgavas iela 1, Riga, Latvia
e-mail: ainasemjonova@gmail.comActive pharmaceutical ingredients (APIs) can have different physical properties (e.g., solubility [1] and bioavailability) depending on polymorph form. Many APIs have low solubility in water. Crystallization of metastable form can enhance solubility and bioavailability [2]....
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Mr Kristaps Saršūns (University of Latvia, Faculty of Chemistry, Department of Physical Chemistry)11/02/2022, 14:15
Solid solutions (SS) are single multicomponent solid phases for which the constituent component ratio can vary in continuum. Along with the composition, also properties of solid solutions are modulated. The changes in composition are often accompanied by a continuous change in some physical and/or chemical properties (e.g., density, solubility, melting point), and more complex properties such...
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Zane Čerpakovska11/02/2022, 14:30
The most common method used to control polymorphism is crystallization. An alternative to the most commonly used solvent crystallization is a mechanochemical treatment of a crystalline substance or a mixture of more than one substance. Mechanochemistry is defined as chemical synthesis induced by external mechanical energy, such as grinding two solids using a mortar-and-pestle, ball-mill, or...
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Kristīne Krūkle-Bērziņa (Latvian Institute of Organic Synthesis)11/02/2022, 14:45
Cyclodextrins (CD’s) are cyclic oligosaccharides widely used in pharmaceutical, food and cosmetic industries as excipients and stabilizers. They are produced by enzymatic transformation of starch, obtained from renewable green sources (potato, corn, etc.). This process is unselective and typically leads to a formation of a mixture of CD’s with various numbers of glucose subunits in the cycle...
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Kaspars Meijers11/02/2022, 15:15
Nitrocelluose-based substances are dangerous because of their instability; therefore, stabilizers are added, but due constant chemical reactions, they are depleted, that’s why for safety of everyone involved, nitrocellulose-based substance stability must be tested. In the last few years Latvia started to test its own munition on chemical stability, which was limited to chromatographic methods,...
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Agris Auce11/02/2022, 15:30
Use of air to water heatpump (AWHP) to reduce CO2 emissions from greenhouse heating were investigated by calculating the running costs of AWHP and natural gas boilers. Real climatic conditions and heating regimes of SIA Rītausma industrial greenhouse production facility in south east of Latvia were used for the calculations. COP of commercially available Hitachi 10kw heating power air-to water...
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Liga Avotina (University of Latvia, Institute of Chemical Physics)11/02/2022, 15:45
Sheep breeding in Latvia in the last decade is stabilized and continues to develop. Since sheep breeding includes producing of wool, it is important for fabrication of textiles and thermoinsulators. However, annually tons of wool fibers, that do not fit to requirements to be used in textile industry, remain as residues. Such wool can be used as sorbent [1] or convert in activated carbon [2]...
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Margarita Baitimirova11/02/2022, 16:00
Graphene – 2D carbon allotrope – is a unique nanomaterial due too its physical properties: semiconductor with zero band gap, high electrical and thermal conductivity, high optical transparency and mechanical strength. Such properties open wide applications of graphene in many fields such as electronics, optoelectronics, thermoelectrics etc. Combination of graphene with other nanomaterials in...
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Edgars Mamis (Institute of Chemical Physics, University of Latvia, CERN)11/02/2022, 16:15
Medical radionuclides as $^{43,44m, 44g,47}$Sc are very promising in “matched theranostic pair” radiopharmaceutical development for cancer treatment. Use of natural titanium as target material for production of $^{43,44m, 44g,47}$Sc radionuclides is favorable in terms of cost and the wide availability of target material, in contrast of using low abundant enriched Ca targets. We report here the...
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Madara Tomele (University of Latvia, Institute of Chemical Physics)11/02/2022, 16:30
Lithium orthosilicate (Li4SiO4) and lithium metatitanate (Li2TiO3) for radiation-induced defect studies have been made using numerous methods including sol-gel, melt-spraying, drip-casting and solid-state reaction process in order to evaluate radiation stability of material for application as tritium breeding ceramics in future thermonuclear fusion reactors [1,2]. Solid-state reaction process...
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Aleksandrs Novikovs (LU CFI, LU FAM DSP)11/02/2022, 16:45
Metallic nanoparticle dispersions for conducting ink preparation
Aleksandrs Novikovs, Boriss Poļakovs
Institute of Solid State Physics, University of Latvia
e-mail: aleksandrs.novikovs@cfi.lu.lvThe aim of this research is to prepare conducting nanoparticle inks, such that it would be possible to print electrical components using a functional ink-jet printer.
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Relevance of the topic... -
Dmitrijs Bogdanovs11/02/2022, 17:00
As the use of ion exchange membranes increases, so does the need to improve them. SPEEK membranes are described using their sulfonation degree (DS) that is directly related to other membrane parameters. The degree of sulfonation is defined as the percentage of re-sulfonated SPEEK units. Therefore, it is necessary to find a cheap, easy-to-perform and accurate method for testing DS.
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