The chemistry of hypervalent halogen species has experienced enormous progress in the last decades, and hypervalent iodine (III) compounds have become common reagents in modern organic synthesis. In sharp contrast, the chemistry of isoelectronic bromine (III) compounds occur to be notably less advanced to date. This dramatic difference obviously is to be connected with the relatively low...
N-Alkylation of readily accessible Ellman’s sulfinamide derivatives has become a routine step in preparation of enantiopure amines. On the other hand, rarely exploited nucleophilic character of the S-atom in tert-butyl sulfinamides can be revealed in a serendipitously discovered intramolecular alkylation. High regio- and stereoselectivity of this transformation allows for facile...
New method for the synthesis of substituted indazoles and 2-aminoquinazolines has been studied and developed. Using invented technique, 2-formylphenylboronic acids can be converted to the target heterocycles in a mild conditions.
Enantiopure cyanohydrins are valuable building blocks in organic and medicinal chemistry [1]. Both functional groups of cyanohydrins (nitrile and hydroxy group) can be easily modified giving access to a variety of valuable organic compounds such as α‑amino acids, α‑hydroxy acids and aziridines.
Herein we present chiral Lewis base-catalyzed synthesis of enantioenriched cyanohydrins...
Over the last decade, high-valent cobalt catalysis has earned a place in the spotlight as a valuable tool for C-H activation and functionalization. The use of cobalt (II) salt catalysts in combination with bidentate directing groups has been proven to be an effective strategy for various C-H bond transformations. Not only cobalt is less expensive alternative to third row noble metals, but also...
Latvian Institute of Organic Synthesis, Aizkraukles 21, Riga LV-1006, Latvia
e-mail:a-pelss@osi.lv
Prostanoids are important class of potent lipid mediators that are involved in the regulation of many biological processes such as inflammation, pain response and fever. This class of compounds has found wide-spread use as pharmaceuticals for the treatment of several diseases including...
Azido groups in nitrogen heterocycles, if adjacent to annular nitrogen, can spontaneously cyclize to fused tetrazole or at least persist in azide-tetrazole equilibrium [1]. Azide-tetrazole valance tautomerism is considered as a reversible intramolecular 1,5-dipolar cycloaddition with azide tautomer being thermodynamically more stable. However, azide formation is endothermic process, thus azide...
Highly luminescent two coordinate linear carbene-metal-amide (CMA, metal= Cu, Ag, Au) complexes with short radiative lifetimes have emerged as a highly promising direction towards TADF materials [1,2]. However, structural diversity of CMAs with potential OLED application is still limited to a handful of N-heterocyclic carbene (NHC) structures. In this report we demonstrate luminescent CMAs...
The abstract is in the attachment.
Malaria is a deadly parasitic infection caused by Plasmodium parasites. The widespread resistance against available antimalarial drugs motivates scientists to develop new therapeutic agents targeting the life cycle of the parasite by novel mechanisms of action.
Plasmepsins (plm) are malarial aspartic proteases which have been proposed as appropriate antimalarial drug targets. It is important...
