11 February 2022
Europe/Riga timezone

MECHANOCHEMICAL PREPARATION OF CRYSTAL FORMS OF SELECTED PHARMACEUTICAL SUBSTANCES

11 Feb 2022, 14:30
15m
Oral presentation Fizikālās ķīmijas sēde Physical Chemistry

Speaker

Zane Čerpakovska

Description

The most common method used to control polymorphism is crystallization. An alternative to the most commonly used solvent crystallization is a mechanochemical treatment of a crystalline substance or a mixture of more than one substance. Mechanochemistry is defined as chemical synthesis induced by external mechanical energy, such as grinding two solids using a mortar-and-pestle, ball-mill, or shaker. Such reactions are classified as Green Chemistry synthesis, prioritizing high yields, mild conditions and low to no use of solvents.
To date, three polymorphic forms of 3-hydroxybenzoic acid have been described. Similarly, crystal structures of three polymorphs have been found for co-crystal formed between urea and barbituric acid.

Primary author

Co-authors

Agris Bērziņš Artis Kons (University of Latvia)

Presentation materials