Vincenza Tinnirello
(Department of Biomedicine, Neurosciences and Advanced Diagnostics (Bi.N.D), University of Palermo, Section of Biology and Genetics, Palermo 90133 Italy)
Plant-derived nanovesicles (PDNVs) are lipoproteic nanostructures naturally produced by cells involved in intra- and interspecies cell-cell communication. They concentrate and carry a multitude of healthful compounds naturally present in plants, simultaneously protecting them from external degradative and oxidative events; for these reasons, they can lead to phenotypic changes also in mammalians. In addition to their natural origin, non-toxicity, and low immunogenicity, the possibility of isolating from large volumes makes them attractive for their use in clinics as a preventive and/or therapeutic strategy for many inflammatory diseases, including inflammatory bowel disease (IBD).This work aims to investigate the biological properties of industrially produced lemon nanovesicles (iLNVs) and to evaluate their protective effects against IBD. Our findings highlight several key aspects that contribute to the understanding of the mechanisms underlying the anti-inflammatory and antioxidant properties of iLNVs, revealing advantages in the management of IBD.
| Presenting author |
Vincenza Tinnirello
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Prof.
Alice Conigliaro
(Department of Biomedicine, Neurosciences and Advanced Diagnostics (Bi.N.D), University of Palermo, Section of Biology and Genetics, Palermo 90133 Italy)
Prof.
Francesca Rappa
(Department of Biomedicine, Neurosciences and Advanced Diagnostics (BIND), Institute of Human Anatomy and Histology, University of Palermo, 90127 Palermo, Italy.)
Dr
Mar Larrosa
(Department of Nutrition and Food Science, School of Pharmacy, Complutense University of Madrid, Madrid, Spain)
Dr
Maria Grazia Zizzo
(Department of Biological, Chemical and Pharmaceutical Sciences and Technologies (STEBICEF), University of Palermo, Palermo 90128 Italy)
Dr
Mariangela Tabone
(Faculty of Biomedical and Health Sciences, Universidad Europea de Madrid, Madrid 28670, Spain)
Mr
Nima Rabienezhad Ganji
(Department of Biomedicine, Neurosciences and Advanced Diagnostics (Bi.N.D), University of Palermo, Section of Biology and Genetics, Palermo 90133 Italy)
Prof.
Riccardo Alessandro
(Department of Biomedicine, Neurosciences and Advanced Diagnostics (Bi.N.D), University of Palermo, Section of Biology and Genetics, Palermo 90133 Italy)
Ms
Roberta Gasparro
(Department of Biomedicine, Neurosciences and Advanced Diagnostics (Bi.N.D), University of Palermo, Section of Biology and Genetics, Palermo 90133 Italy)
Prof.
Rosa Serio
(Department of Biological, Chemical and Pharmaceutical Sciences and Technologies (STEBICEF), University of Palermo, Palermo 90128 Italy)
Dr
Stefania Raimondo
(Department of Biomedicine, Neurosciences and Advanced Diagnostics (Bi.N.D), University of Palermo, Section of Biology and Genetics, Palermo 90133 Italy)
Vincenza Tinnirello
(Department of Biomedicine, Neurosciences and Advanced Diagnostics (Bi.N.D), University of Palermo, Section of Biology and Genetics, Palermo 90133 Italy)
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