Speaker
Description
According to the WHO, over 55 million people worldwide were living with dementia in 2023, with associated health care costs reaching $1 trillion. Projections suggest these figures will double every two decades, highlighting a critical global health challenge. Advances in life sciences are expected to play a pivotal role within an increasingly aging population. [1]
The dysfunction of the nervous system seen in various neurodegenerative conditions has been attributed to the imbalance of free metal ions and oxidative stress. For instance, in Alzheimer's disease, elevated levels of copper and iron within beta-amyloid plaques are believed to contribute to increased oxidative damage in specific brain regions. Current studies aim to mitigate these effects by sequestering transition metals to prevent protein aggregation and by converting their harmful oxidative properties into beneficial antioxidant activities. [2]
A class of tetraaza-pyridinophane macrocycles that can bind Fe(II) and Cu(II) has been synthesized, and their antioxidant capabilities have been explored. Their superoxide dismutase and catalase/peroxidase activities has been modulated by adjusting the pyridine electron density with different substituents ranging from COOMe to OH groups. [3, 4]
| Presenting author | Pablo Navarro-Madramany |
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